Both compounds showed nano-molar activities against SARS-CoV-2 virus, which were superior to GC376 for anti-HCoV-43, and equivalent to the standard molecule remdesivir. In addition, they inhibited about 90 % HCoV-OC43 replication in BHK-21 cells at 1 µM. Further evaluation of MST assay and enzymatic kinetics experiment in vitro showed that they had a certain affinity to SARS-CoV-2 M pro and were both non-competitive inhibitors. Fortunately, Acriflavine (ACF) and Proflavine Hemisulfate (PRF) with the same acridine scaffold were picked out for their good inhibitory activity against M pro with IC 50 of 5.60 ± 0.29 µM and 2.07 ± 0.01 µM, respectively. In order to get potential anti-SARS-CoV-2 agents, we established an enzymatic assay using a fluorogenic substrate to screen the inhibitors of M pro. M pro is an intriguing antiviral target for interfering with viral RNA replication and transcription. Rulers of the Liang Dynasty 梁 (502-557)Ĭapital: Jiankang 建康 (today's Nanjing 南京, Jiangsu.The evolving SARS-CoV-2 epidemic buffets the world, and the concerted efforts are needed to explore effective drugs. In 557, Chen Baxian deposed Xiao Fangzhi and founded his own dynasty named Chen 陳. 555), and Xiao Cha 蕭詧, were finally ended by Chen Baxian 陳霸先 who made Xiao Fangzhi 蕭方智 (posthumous title Emperor Jing 梁敬帝, r. 552), Xiao Yuanming 蕭淵明 (the Marquis of Zhenyang 貞陽侯, r. The power struggles after Hou Jing's death in 552, carried out by the princes Xiao Lun 蕭綸, Xiao Yi 蕭繹 (posthumous title Emperor Yuan 梁元帝, r. Since the beginning of the Eastern Jin period, this was the first time that the lower Yangtze area was seriously devastated by military activities. 551), and finally made himself emperor of a Han dynasty 漢. 549-550), afterwards Xiao Dong 蕭棟 (the Prince of Yuzhang 豫章王, r. Hou Jing penetrated into the palace and made Xiao Zhengde emperor, then Xiao Wang 蕭網 (posthumous title Emperor Jianwen 梁簡文帝, r. The rebels captured the capital Jiankang, and during siege Emperor Wu starved to death. Hou Jing later conspired with Xiao Zhengde 蕭正德 to overthrow Emperor Wu and assembled a large army of rebels. A refugee from the Eastern Wei empire 東魏 (534-550), Hou Jing 侯景, supported Emperor Wu in his ambitions to reconquer northern China. He also promoted the spread of Buddhism among the southern aristocracy.ĭuring Emperor Wu's reign the Northern Wei empire disintegrated, and a lot of refugees from the Northern Wei court sought refuge in the south, looking for political support, like Yuan Hao 元顥. During his long rule, important anthologies ( Wenxuan 文選, Yutai xinyong 玉臺新詠) and literary critiques ( Shipin 詩品, Wenxin diaolong 文心雕龍) were compiled. Emperor Wu himself was an erudite scholar, he composed poems, wrote essays and patronized writers, poets, and artists. He replaced the nine-rank system ( jiupin 九品) for state officials from the Wei period 魏 (220-265) by sixteen classes ( shiliuban 十六班) that could only be entered after graduating from the National University ( taixue 太學) where the Confucian Classics constituted the curriculum. He neither provoked his own princes and local governors by appointing the infamous spies of the document clerks of the central government, nor tried he to prevent the ambitions of the local gentry from obtaining high governmental posts. Nonetheless, after founding his own dynasty, he switched over to a mild civilian government and spared the old princes of the Song and Qi dynasties. 502-549) was an experienced military leader. 502-549), who is known in history as a famous poet and patron of Buddhism.Īs regional inspector ( cishi 刺史) of Yongzhou 雍州 at the border to the Northern Wei empire, Xiao Yan 蕭衍 (posthumous title Emperor Wu of the Liang 梁武帝, r. It was founded by Xiao Yan 蕭衍, known as Emperor Wu 梁武帝 (r. The Liang dynasty 梁 (502-557) was the third of the Southern Dynasties 南朝 (420~589).
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